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A Magnetic Nanobead-Based Read-Out Procedure for Rapid Detection of DNA Molecules

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The presented measurement and data analysis procedure reduces the read-out time for the volume-amplified magnetic nanobead detection assay from ~30 min to only 2 min, providing fast, sensitive detection of DNA molecules. The molecular detection and amplification protocol was verified using samples containing rolling circle-amplified DNA products formed from synthetic Vibrio cholerae target DNA, with a limit of detection of 5 pM. The developed read-out method could be used to rapidly identify pathogens in a variety of applications including target screening in hospitals with limited resources, in out-patient settings and in the field.
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Keywords: Brownian Relaxation; DNA Macromolecules; Magnetic Nanobeads; Rapid Detection; Rolling Circle Amplification

Document Type: Research Article

Affiliations: 1: Department of Engineering Sciences, Uppsala University, Uppsala, 75121, Sweden 2: Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, 17121, Sweden

Publication date: 2017-04-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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