Gold-Coated Iron Oxide Nanoparticles as a T 2 Contrast Agent in Magnetic Resonance Imaging
Abstract:Gold-coated iron oxide (Fe3O4) nanoparticles were synthesized for use as a T 2 contrast agent in magnetic resonance imaging (MRI). The coated nanoparticles were spherical in shape with an average diameter of 20 nm. The gold shell was about 2 nm thick. The bonding status of the gold on the nanoparticle surfaces was checked using a Fourier transform infrared spectrometer (FTIR). The FTIR spectra confirmed the attachment of homocysteine, in the form of thiolates, to the Au shell of the Au-Fe3O4 nanoparticles. The relaxivity ratio, R 2/R 1, for the coated nanoparticles was 3-fold higher than that of a commercial contrast agent, Resovist, which showed the potential for their use as a T 2 contrast agent with high efficacy. In animal experiments, the presence of the nanoparticles in rat liver resulted in a 71% decrease in signal intensity in T 2-weighted MR images, indicating that our gold-coated iron oxide nanoparticles are suitable for use as a T 2 contrast agent in MRI.
Document Type: Research Article
Publication date: July 1, 2012
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