Differentiation of Bacteria Cell Wall Using Raman Scattering Enhanced by Nanoparticle Array
Authors: Liu, T.-Y.; Chen, Y.; Wang, H.-H.; Huang, Y.-L.; Chao, Y.-C.; Tsai, K.-T.; Cheng, W.-C.; Chuang, C.-Y.; Tsai, Y.-H.; Huang, C.-Y.; Wang, D.-W.; Lin, C.-H.; Wang, J.-K.; Wang, Y.-L.
Source: Journal of Nanoscience and Nanotechnology, Volume 12, Number 6, June 2012 , pp. 5004-5008(5)
Publisher: American Scientific Publishers
Abstract:We have fabricated surface-enhanced Raman scattering (SERS) substrates based on arrays of silver nanoparticles grown on porous anodic alumina templates. Using this nanotechnology platform, label-free and high-speed detection of bacteria are achieved. SERS spectra of various bacteria including Staphylococcus Aureus (Gram-positive bacterium), Klebsiella Pneumoniae (Gram-negative bacterium), and Mycobacterium Smegmatis (Mycobacterium) were recorded. The highly reproducible SERS-based technological platform is capable of differentiating different kinds of bacteria by PCA, LDA, clustering analysis, and SVM methods, which provides promising opportunity for biosensing of clinical microbes.
Document Type: Research Article
Publication date: June 1, 2012
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