Growth of E18 Rat Hippocampal Neuronal Cells on Nanostructured Surfaces for Enhanced Electrical Stimulation and Recording
Abstract:We have prepared gold nanowire arrays inside nanoporous alumina templates with the goal towards neuronal interfacing and electrical recording from neurons. We have investigated biofunctionaliza-tion of such gold nanowire arrays (GNWs) and gold nanofilm (GNF) platforms to understand its impact on neuronal attachment and growth. Poly-D-Lysine (PDL) was coated on the nano-templates surfaces for adhesion of neurons which also enhanced the neuronal growth. Optical microscopy and scanning electron microscopy images revealed strong affinity and improved growth of neurons on PDL-coated surfaces. Such results will impact future investigation of stimulation and recording of electrical activity on nanoscale surfaces.
Document Type: Research Article
Publication date: March 1, 2012
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