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Effects of PEG Length and Iron Oxide Nanoparticles Size on Reduced Protein Adsorption and Non-Specific Uptake by Macrophage Cells

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Abstract:

At present, the studies showed that applications of magnetic iron oxide nanoparticels in vivo are hampered by their non-specific uptake by the innate immune system. And surface PEGylation of the nanoparticles maybe a feasible approach to escape from the reticular-endothelial system for a long blood circulation half-life. In this paper, we synthesized two sizes of monodisperse nanoparticles and studied the effects of PEG length on reduced protein adsorption and non-specific uptake by macrophage cells for an ideal material with a relatively long blood half-life. The results show that small nanoparticles with high molecular weight PEGylation may be a more applicable candidate due to their size effect and high efficiency in reducing protein adsorption.

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2012.5753

Publication date: March 1, 2012

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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