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Photodynamic Effect of Mesoporous Material: Titanium Dioxide Whiskers on SMMC-7721 Cells

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Abstract:

In this report, we have fabricated a novel nanomaterial, titanium dioxide whiskers (TiO2Whs), and evaluate its photodynamic characters on Rhodamine B, where TiO2Whs exhibit better photocatalytic activity than titanium dioxide nanoparticles (TiO2NPs). After testing the biocompatibility, we further investigated the effects of TiO2Whs on human hepatocarcinoma cells (SMMC-7721 cells) under UV illumination from cell level, concentration-dependent effect level, time-dependent effect level, and finally genomic apoptosis level. Our results showed that TiO2Whs possess more obviously photo-killing effect on cancer cells compared with that of TiO2NPs. These studies implied that the novel nanomaterial, TiO2Whs, could be utilized as a promising biomedical agent and would have enormous potential application in photodynamic therapy for cancer treatment in the future.

Keywords: CANCER THERAPY; PHOTODYNAMIC EFFECT; RHODAMINE B; TITANIUM DIOXIDE WHISKERS; UV IRRADIATION

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2012.5150

Publication date: 2012-02-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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