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Investigation of Biological Property of Nanohydroxyapatite Materials

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Abstract:

The biological effects of nanohydroxyapatites and its cell toxicity have been studied using the MTT and ALP method, infrared spectrum of absorption and electrophoresis method, respectively. The nanohydroxyapatites are prepared and made by using sol–gel method, in which the parameters of process and reaction are controlled as: pH > 9, Ca/P = 1.67, sintering temperature of 1100 °C and sintering time 2 hours. Studied results show that nanohydroxyapatites can interact with human serum albumin and change its second structure and weight of molecules. We find that the nanohydroxyapatites and complex of nanoHAP + nanoCrO2 can all restrain the proliferation of MG63 cells, but their toxicities are first degree or minor, the toxicity of the complex is smaller than that of pure nanohydroxyapatites.

Keywords: BIOLOGICAL FUNCTION; CELL PROLIFERATION; ELECTROPHORESIS; HUMAN SERUM ALBUMIN; INFRARED SPECTRUM; MOLECULAR STRUCTURE; NANOHYDROXYAPATITE; TOXICITY

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2012.5154

Publication date: February 1, 2012

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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