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Collapse in Binary Phospholipid Monolayers at the Air/Water Interface

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Abstract:

The behavior in the stochastic collapse of lipid monolayers of a 7:3 mixture of DPPC (dipalmitoylphosphatidylcholine) and POPG (palmitoyloleoylphosphatidylglycerol), a model system of pulmonary surfactant assembly, was studied using Langmuir isotherms, fluorescence microscopy, and atomic force microscopy. The monolayers at the air-water interface appeared to be phase separated under compression and retained the continuous liquid-expanded phase network surrounding islands of condensed phase even at a surface pressure approaching 70 mN/m. When the two-dimensional monolayers were compressed beyond the equilibrium surface pressure, they collapsed and assumed a three-dimensional formation. Collapse events involved folding of the monolayer on a micron scale, and each event produced a macroscopic jerk of the layer. The distribution of waiting times between events was estimated to be an exponential function, indicating that the events were independent. Folded regions coexisted with the flat monolayer, remained attached to the interface, and reversibly reincorporated into the monolayer upon expansion.

Keywords: FLUORESCENCE; FOLDING; LIPID; MONOLAYER; PHASE TRANSITION

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2012.5397

Publication date: January 1, 2012

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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