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Controlling Microstructure of Three-Dimensional Scaffolds from Regenerated Silk Fibroin by Adjusting pH

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For tissue engineering, it is very important to design and control the pore architecture of three-dimensional (3D) polymeric scaffolds, which plays an important role in directing tissue formation and function. In this study, 3D porous silk fibroin scaffolds produced using a freeze drying technique were prepared at pHs ranging from 5 to 9. The effects of pH on the pore microstructure of the silk fibroin scaffold were examined by rheometry, FESEM and FTIR. Different pore structures were formed according to the pH of silk fibroin because silk fibroin exhibits water-like behavior under basic conditions and gel-like behavior under acidic conditions.


Document Type: Research Article


Publication date: January 1, 2012

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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