Superparamagnetic Iron Oxide Nanoparticles for Delivery of Tissue Plasminogen Activator

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Abstract:

Magnetic nanoparticle (MNP) modified by carboxymethyl dextran (CMD) was synthesized and characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, superconducting quantum interference device, dynamic light-scattering, thermogravimetric analysis, and X-ray diffraction. CMD coating on the particle surface provides abundant –COOH functional groups for conjugating with a thrombolytic drug, recombinant tissue plasminogen activator (rtPA). CMD-coated MNP (CMD-MNP) prepared with higher CMD/MNP ratios had higher CMD content, less iron content, more –COOH surface groups, smaller hydrodynamic diameter, and smaller saturation magnetization. The in vitro biocompatibility study using lactate dehydrogenase assays indicated that CMD-MNP elicited no cell cytotoxicity. The optimum drug loading could be achieved by contacting 0.25 mg rtPA with 5 mg CMD-MNP where all rtPA is immobilized to the magnetic nanocarrier with full retention of its thrombolytic activity.

Keywords: DEXTRAN; DRUG DELIVERY; MAGNETIC NANOPARTICLES; THROMBOLYSIS; TISSUE PLASMINOGEN ACTIVATOR

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3953

Publication date: December 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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