Preparation of Polymeric Micelles Consisting of Poly(propylene glycol) and Poly(caprolactone)

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Abstract:

The ring-opening polymerization of ε-caprolactone (CL) was carried out with polypropylene glycol (PPG) as an initiator in the presence of the monomer activator HCl·Et2O to synthesize poly(ε-caprolactone)–poly(propyleneglycol)–poly(ε-caprolactone) (PCL–PPG–PCL) triblock copolymers with change of length PPG and PCL. The micelle formation of PCL–PPG–PCL triblock copolymers in an aqueous phase was confirmed by NMR, dynamic light scattering and fluorescence techniques. The critical micelle concentration (CMC) of the PCL–PPG–PCL triblock copolymers, determined from fluorescence measurements, was in range of 1.4 × 10−3–4.6 × 10−3 mg/ml with dependence on block lengths of PPG and PCL. The partition equilibrium constant, K v, which is an indicator of the hydrophobicity of the micelles of the PCL–PPG–PCL triblock copolymers in aqueous media, was also changed with dependence on length PPG and PCL. We confirmed that the PCL–PPG–PCL triblock copolymers formed micelles and hence may be potential hydrophobic drug carriers.

Keywords: CMC; EPSI-CAPROLACTONE; MICELLE; POLYPROPYLENE GLYCOL; TRIBLOCK COPOLYMER

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3954

Publication date: December 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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