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RecA Protein Mediated Nano-Scale Patterning of DNA Scaffolds

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Abstract:

Molecular lock-and-key functionality inherent to a large number of biological molecules is arguably one of the most promising potential routes for building complex nanostructures and eventually nanoelectronic devices by self-assembly. Here, we report the use of the DNA-binding protein RecA as a tool for patterning DNA scaffolds site-specifically and in a programmable way at the nanometrescale. This is demonstrated by patterning a 3 kilo-base-pair double-stranded DNA molecule at ten different locations with nanometre-sized RecA-based nucleoprotein filaments. This protein-based molecular patterning technique, which is site-specific, programmable, and scalable, offers a potential basis for molecular lithography applications, and opens previously inaccessible routes towards the fabrication of complex functional nano-electronic devices by self-assembly.

Keywords: DNA SCAFFOLDS; MOLECULAR LITHOGRAPHY; NANOSCALE PATTERNING; RECA PROTEIN

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3937

Publication date: December 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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