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Hydrothermal Synthesis of a Highly Sensitive T2-Weigthed MRI Contrast Agent: Zinc-Doped Superparamagnetic Iron Oxide Nanocrystals

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Abstract:

A highly efficient hydrothermal strategy for the synthesis of zinc-doped superparamagnetic iron oxide nanocrystals (SPION:Zn) with lower toxicity and improved sensitivity has been demonstrated. The saturation magnetizations of as-synthesized SPION:Zn were demonstrated to be Zn-dependent and could be tuned from 41.88 emu/g to 79.23 emu/g by changing the amount of Zn. As-synthesized hydrophobic SPION:Zn could be efficiently transferred into water phase through a ultrasonic process with the assistance of cetyltrimethylammonium bromide (CTAB) surfactant. As-obtained CTAB stabilized SPION:Zn was exploited as a MR enhanced contrast agent, and its T 2 relaxivity coefficient (r 2) was found to be as high as 342.09 mM−1 s−1.

Keywords: SUPERPARAMAGNETIC IRON OXIDE NANOCRYSTALS; T2-WEIGHTED MRI; ZINC-DOPING

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3934

Publication date: December 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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