Hydrothermal Synthesis of a Highly Sensitive T2-Weigthed MRI Contrast Agent: Zinc-Doped Superparamagnetic Iron Oxide Nanocrystals
Abstract:A highly efficient hydrothermal strategy for the synthesis of zinc-doped superparamagnetic iron oxide nanocrystals (SPION:Zn) with lower toxicity and improved sensitivity has been demonstrated. The saturation magnetizations of as-synthesized SPION:Zn were demonstrated to be Zn-dependent and could be tuned from 41.88 emu/g to 79.23 emu/g by changing the amount of Zn. As-synthesized hydrophobic SPION:Zn could be efficiently transferred into water phase through a ultrasonic process with the assistance of cetyltrimethylammonium bromide (CTAB) surfactant. As-obtained CTAB stabilized SPION:Zn was exploited as a MR enhanced contrast agent, and its T 2 relaxivity coefficient (r 2) was found to be as high as 342.09 mM−1 s−1.
Document Type: Research Article
Publication date: December 1, 2011
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