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Aqueous Synthesis of Au:CdTe Nanocrystals for Noninvasive Fluorescence Imaging in Living Cells

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Abstract:

The gold-doped cadmium telluride (Au:CdTe) nanocrystals were synthesized by aqueous solution route using L-glutathione and L-cysteine as stabilizers. As-prepared Au:CdTe nanocrystals have good monodispersity and a zinc-blende structure. Compared with undoped CdTe nanocrystals, the Au:CdTe nanocrystals exhibited improved photostability, higher cellular affinity, and lower cytotoxicity. The Au:CdTe nanocrystals were used as probes for long-term noninvasive fluorescence imaging in living cells (The human lung epithelial carcinoma A549 cells). They could be endocytic uptaken by A549 cells and stably labeled the cytoplasm for over a week. By transmission electron microscopy (TEM) analysis, the Au:CdTe NCs could be observed in vesicles after being uptaken by A549 cells. Doping semiconductor nanocrystals with gold has the potential to engineer the photostability and biocompatibility for extensive biomedical applications. This work developed a facile aqueous solution route to synthesize gold-doped semiconductor nanocrystals and may assist in the design of doped nanobiomaterials.

Keywords: BIOCOMPATIBILITY; CYTOTOXICITY; FLUORESCENCE IMAGING; GOLD-DOPED; NANOCRYSTALS

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.5019

Publication date: December 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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