Skip to main content

Characteristics and Photo-Responsive Release Property of Liposome Containing 7-Acetoxy Coumarin

Buy Article:

$113.00 plus tax (Refund Policy)

Abstract:

A photo-responsive liposome was developed by loading 7-acetoxy coumarin (ATC) in egg phosphatidylcholine (EPC) liposome. ATC was derivetized from 7-hydroxy coumarin using sodium acetate. The ATC-loaded liposomes were prepared by suspending the dry mixture film of ATC/EPC in distilled water and sonicating the suspension. When the ATC to EPC ratio was less than 1:8, homogeneous liposomal suspensions were obtained without any precipitate. On 1H NMR spectra, the unsaturated chains of liposomal EPCs were somewhat deteriorated by a subsequent irradiation, the irradiation of λ = 365 nm and then the irradiation of λ = 254 nm. On TEM photos, the size of liposomes incorporating ATC markedly increased by the subsequent irradiation. Photo-dimerization (under λ = 365 nm) and de-dimerization (under λ = 254 nm) of ATC took a place even in EPC liposomes. Upon the irradiation of λ = 254 nm, liposome containing ATC dimers exhibited an enhanced release of 5(6)-carboxyfluorescein compared with liposome containing ATC monomer and liposome free of ATC. The de-dimerization of ATC dimers is believed to fluidize the liposomal membrane and promote the release.

Keywords: 7-ACETOXY COUMARIN; EGG PHOSPHATIDYLCHOLINE; LIPOSOMES; PHOTO-RESPONSIVE RELEASE

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2011.4996

Publication date: 2011-11-01

More about this publication?
  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more