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New Synthesis Approach for Hybrid Gd(III)–Loaded Nanocrystalline TiO2 as Potential Magnetic Resonance Imaging Contrast Agents

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Abstract:

A new aqueous "in situ and one pot" method to elaborate surface-functionalized Gd(III)–doped anatase TiO2 nanoparticles, starting from heterometallic/heteroleptic Gd–Ti alkoxides, is reported. Full characterization and thermal behaviour of the nanomaterials demonstrate that this molecular approach offers the convenience of working under soft temperature and pH conditions in order to allow fine tuning of the organic surface functionalization and gadolinium doping. In vitro phantom images exhibit potential MRI T1-contrast agent properties.

Keywords: ALKOXIDE; GADOLINIUM; HYBRID; MRI T1-CONTRAST AGENTS; NANOPARTICLE; TIO2

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.4287

Publication date: October 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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