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Synthesis of Biomimetic Poly[2-(methacryloyloxy)ethyl phosphorycholine]-Coated Magnetite Nanoparticles via Surface-Initiated Atom Transfer Radical Polymerization

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Abstract:

Modification of magnetite nanoparticles with biomimetic poly[2-(methacryloyloxy)ethyl phosphorycholine] (poly(MPC)) via surface-initiated atom transfer radical polymerization (ATRP) was carried out. Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analyses (TGA) and ζ potential studies indicated that well defined poly(MPC) was successfully grafted on the surface of magnetite nanoparticles. X-ray diffraction results showed the structure of magnetite nanoparticles after surface modification was not changed. The poly(MPC)-coated magnetite nanoparticles had a mean transmission electron microscopy (TEM) diameter of 11 ± 1.5 nm. The resulting nanomaterials were superparamagnetic at room temperature, exhibited good colloidal stability in aqueous media and good responsibility to magnetic field. Such magnetite nanoparticles with biomimetic surface have potential application in prolonging circulation time in vivo.

Keywords: BIOMIMETIC; LONG CIRCULATION TIME; MAGNETITE NANOPARTICLES; POLY[2-(METHACRYLOYLOXY)ETHYL PHOSPHORYCHOLINE]; SURFACE-INITIATED ATOM TRANSFER RADICAL POLYMERIZATION

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2011.4968

Publication date: 2011-10-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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