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Selective Separation of Fluorescent-Magnetic Nanoparticles with Different Magnetite-Doping Levels

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Fluorescent-labeled magnetic nanoparticles were explored as a biomedical agent for selective magnetic separation. By adjusting the loading volume of citrate-stabilized magnetites during a sol–gel reaction with silicon alkoxide, magnetites were simultaneously embedded into both the surface and inside the silica matrix, consequently leading to magnetic nanoparticles with different doping levels of magnetites. For endowing them with multifunctional tools in biomedical fields, magnetic nanoparticles were further encapsulated with silica thin layer labeled with fluorescent organic dyes (such as Alexa Fluor 488 and 594). Fluorescent-magnetic nanoparticles with different magnetism successfully displayed the differential separation of fluorescence spectra under an external magnetic field.


Document Type: Research Article


Publication date: May 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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