Fabrication of Nanoconcave Surface for Cell Immobilization in Cell-Based Chip

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Abstract:

Nanostructured surface such as nanoconcave shape can be utilized as a bioplatform to immobilize cells. In this study, we present fabrication of Au-coated nanoconcave surface and some possibility of cell immobilization. Long-range ordered periodic patterns with concave shape were formed on aluminum substrate by electrochemical anodization process. The morphology and topography of nanoconcave surface was investigated by atomic force microscopy and scanning electron microscopy. The pore–pore distance and the pore depth of nanoconcave pattern were measured at 105 ± 5 nm and 30 ± 2 nm, respectively. After Au deposition, the pore depth within Au-coated concave surface was 15 ± 2 nm. The topography of HeLa cells immobilized on the nanoconcave surface was observed by AFM combined with confocal microscopy. The result expected that the Au-coated nanoconcave surface may be used as new culture substrate for cells immobilization in cell-based chip.

Keywords: ANODIZATION; AU-COATED NANOCONCAVE SURFACE; CELL-BASED CHIPS; HELA CELLS IMMOBILIZATION

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3674

Publication date: May 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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