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Comparison Study on the Antibacterial Activity of Nano- or Bulk-Cerium Oxide

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Due to the unique physical and chemical properties, nanosized cerium oxide (n-CeO2) has attracted considerable interest in many fields of research. The potential, the growing use and the mass production of n-CeO2 have stimulated research on their potential impact on the environment and human health. However, the toxicological definition for CeO2 nanoparticles (NPs) is still quite controversial. In the present work, we evaluated the antibacterial activity of CeO2 NPs sized ca. 7 nm (7-CeO2), ca. 25 nm (25-CeO2) and their bulk counterpart (b-CeO2), using gram-negative Escherichia coli (E. coli). Our results suggest that all the three types of CeO2 particles have antibacterial activity, and both the NPs are more toxic than b-CeO2. The rise in intracellular ROS level induced by direct contact of particles with the surface of E. coli was involved in the mechanism for the antibacterial activity of CeO2 NPs. Exposure to 25-CeO2 could also impair the integrity of the outer membrane within E. coli cells. Due to agglomeration and negligible effect on membrane integrity, 7-CeO2 did not exhibit greater antibacterial activity than 25-CeO2.


Document Type: Research Article


Publication date: 2011-05-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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