Authors: Kuang, Yashu; He, Xiao; Zhang, Zhiyong; Li, Yuanyuan; Zhang, Haifeng; Ma, Yuhui; Wu, Zhenqiang; Chai, Zhifang

Source: Journal of Nanoscience and Nanotechnology, Volume 11, Number 5, May 2011 , pp. 4103-4108(6)

Publisher: American Scientific Publishers

Abstract:

Due to the unique physical and chemical properties, nanosized cerium oxide (n-CeO₂) has attracted considerable interest in many fields of research. The potential, the growing use and the mass production of n-CeO₂ have stimulated research on their potential impact on the environment and human health. However, the toxicological definition for CeO₂ nanoparticles (NPs) is still quite controversial. In the present work, we evaluated the antibacterial activity of CeO₂ NPs sized ca. 7 nm (7-CeO₂), ca. 25 nm (25-CeO₂) and their bulk counterpart (b-CeO₂), using gram-negative Escherichia coli (E. coli). Our results suggest that all the three types of CeO₂ particles have antibacterial activity, and both the NPs are more toxic than b-CeO₂. The rise in intracellular ROS level induced by direct contact of particles with the surface of E. coli was involved in the mechanism for the antibacterial activity of CeO₂ NPs. Exposure to 25-CeO₂ could also impair the integrity of the outer membrane within E. coli cells. Due to agglomeration and negligible effect on membrane integrity, 7-CeO₂ did not exhibit greater antibacterial activity than 25-CeO₂.

Keywords: CERIUM OXIDE; ANTIBACTERIAL ACTIVITY; PARTICLE SIZE

Document Type: Research article

DOI: http://dx.doi.org/10.1166/jnn.2011.3858

Publication date: 2011-05-01

More about this publication?

• Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
• Editorial Board
• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Technology
• By this author: Kuang, Yashu ;  He, Xiao ;  Zhang, Zhiyong ;  Li, Yuanyuan ;  Zhang, Haifeng ;  Ma, Yuhui ;  Wu, Zhenqiang ;  Chai, Zhifang

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers