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Screening of Formulation Variables for the Preparation of Poly(-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine

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Abstract:

In this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 24−1 factorial experimental design was used to study the influence of four different independent variables (polymer, oily phase, Span 60 and Tween 80) on nanocapsule characteristics (size, polydispersion index, zeta potential) and drug loading capability. Best results were obtained using an aqueous formulation comprising 100 mg of polymer, 200 mg of oily phase, 40 mg of Span 60 and 60 mg of Tween 80 in a final volume of 10 mL which produced a colloidal system with particle size of 188 nm, zeta potential −32 mV, polydispersion index 0.07, and benzocaine association efficiency >87%. These findings open the way for future clinical studies using such formulations.

Keywords: 2 4-1 FACTORIAL EXPERIMENTAL; EXPERIMENTAL DESIGN; LOCAL ANESTHETIC; NANOPARTICLES; POLYMERIC NANOCAPSULES

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3547

Publication date: March 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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