Determination of Serotonin on a Glassy Carbon Electrode Modified by Electropolymerization of Meso-Tetrakis(2-aminophenyl)porphyrin and Single Walled Carbon Nanotubes
A chemically modified electrode [poly(TAPP)-SWNT/GCE] was prepared by electropolymerization of meso-tetrakis(2-aminophenyl)porphyrin (TAPP)-single walled carbon nanotubes (SWNT) on the surface of a glassy carbon electrode (GCE). This modified electrode was employed as an electrochemical biosensor for the determination of serotonin concentration and exhibited a typical enhance effect on the current response of serotonin and lower oxidation overpotential. The biosensor was very effective to determined 5-HT in a mixture. The linear response was in the range 2.0 × 10−7 to 1.0 × 10−5 M, with a correlation coefficient of 0.999 [ip (μA) = 3.406 C (μM) + 0.132] on the anodic current, with a detection limit of 1 × 10−9 M. Due to the relatively low currents and different potentials in the electrochemical responses to ascorbic acid and dopamine, the modified electrode is a useful and effective sensing device for the selective and sensitive serotonin determination in the presence of ascorbic acid and dopamine.
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Document Type: Research Article
Publication date: 2011-03-01
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