Synthesis and Characterization of 3-[131I]Iodo-L-Tyrosine Grafted Fe3O4@SiO2 Nanocomposite for Single Photon Emission Computed Tomography (SPECT) and Magnetic Resonance Imaging (MRI)
Abstract:In this study, we have successfully developed 3-[131I]iodo-tyrosine grafted Fe3O4@SiO2 nanocomposites for dual potential tumor imaging agent for SPECT and MRI. Fe3O4 nanoparticle was synthesized through thermal decomposition and Fe3O4@SiO2 was prepared by reverse microemulsion method. After conjugating aminopropyltriethoxysiliane, L-tyrosine was introduced by amide coupling reaction. Finally, [131I]iodide was labeled on L-tyrosine grafted Fe3O4@SiO2 nanocomposite by aromatic iodination using chloramine-T.
Document Type: Research Article
Publication date: February 1, 2011
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