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Response of Fetal Rat Calvarial Cells to Nanotubular Titanium Oxide Surface

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Abstract:

This study examined the cell response to a TiO2 nanotubular surface (Ti–NT) for future biomedical applications. The level of cell attachment and spreading at 20 min and 60 min was evaluated by SEM. IL-6 and PGE2 secretion was evaluated by ELISA. In SEM analysis, the Ti–NT surface had more fully spread cells compared to the machined titanium surface (Ti–S). ELISA revealed that the level of IL-6 and PGE2 production was higher on the Ti–NT than on the Ti–S. These results suggest that a surface treatment with a nanotubular TiO2 surface enhances the early osteoblast responses, such as cell spreading and cytokine release, which are important for subsequent cell functions and bone healing in vivo.

Keywords: ANODIZATION; CYTOKINES; NANOTUBE; OSTEOBLAST

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3413

Publication date: February 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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