Enhanced Anti-Cancer Effect of 5-Fluorouracil Loaded into Thermo-Responsive Conjugated Linoleic Acid-Incorporated Poloxamer Hydrogel on Metastatic Colon Cancer Models
Abstract:Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.
Document Type: Research Article
Publication date: 2011-02-01
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