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Enhanced Anti-Cancer Effect of 5-Fluorouracil Loaded into Thermo-Responsive Conjugated Linoleic Acid-Incorporated Poloxamer Hydrogel on Metastatic Colon Cancer Models

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Abstract:

Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.

Keywords: 5-FLUOROURACIL; COLON CANCER; CONJUGATED LINOLEIC ACID-COUPLED PLURONIC F127

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3403

Publication date: February 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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