Supramolecular Assembly and Antitumor Activity of Multiwalled Carbon Nanotube–Camptothecin Complexes
Abstract:The novel supramolecular complexes were prepared with a water-insoluble anticancer drug camptothecin (CPT) loading onto functionalized multiwalled carbon nanotubes via -stacking, in order to improve their solubility and antitumor activity. The multiwalled carbon nanotubes were firstly coated with the tri-block copolymer (Pluronic P123) to render high aqueous solubility. The copolymer-coated multiwalled carbon nanotubes can effectively form non-covalent supramolecular complexes with camptothecin. The supramolecular assembly of the complexes (f-MWNTs–CPT) were systematically characterized by transmission electron microscopy (TEM), UV–vis spectrophotometry (UV), fluorescence spectrophotometry, atomic force microscopy (AFM) and electrochemical impedance spectroscopy (EIS). Furthermore, in vitro cytotoxicity studies of f-MWNTs–CPT supramolecular complexes using the MTT assay exhibit enhanced antitumor activity, suggesting that the functionalized multiwalled carbon nanotubes can facilitate intracellular delivery of anticancer drug and improve drug activity.
Document Type: Research Article
Publication date: 2011-02-01
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