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Fabrication of Gold Nanoparticle Modified ITO Substrate to Detect -Amyloid Using Surface-Enhanced Raman Scattering

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Abstract:

Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by the deposition of -amyloid (A) peptide and the formation of neurofibrillary tangles in neurons. The A peptide is a key molecule in the pathogenesis of Alzheimer's disease and an important marker for early diagnosis. Surface-enhanced Raman scattering (SERS) has recently been attracting keen interest in various fields such as for biosensors or immunoassays. In this study, gold nanoparticles (Au NPs) were electrochemically deposited on an indium tin oxide (ITO) substrate at different heights. A antibodies were immobilized on the Au-NP-coated ITO substrate, after which the interactions between the antigen and the antibody were determined via SERS spectroscopy. The SERS responses were strongest at the Au NP array height of 91 nm, with a good linear relationship that corresponded to the change in the concentration of the antigen. This Au-NP-array-mediated SERS can be applied with a highly sensitive immunodetection biosensor.

Keywords: AU-NANOPARTICLES; BETA-AMYLOID; IMMUNOASSAY; NANOBIOCHIP; RAMAN SPECTROSCOPY; SERS

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2011.3268

Publication date: January 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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