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Release of Folic Acid in Mesoporous NFM-1 Silica

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Mesoporous NFM-1 silica with folic acid as template was prepared taking advantage of the supramolecular self-assembly of pterin groups and their abilities to form hexagonal liquid crystal phases. NFM-1 materials with the varied morphologies such as fiber, chiral twisting long-rod, gyroid, and amorphous particles were prepared by varying the amount of the co-structure directing agent, stirring speed and changing pH value of the synthesis. The release kinetics of NFM-1 samples with different morphologies were studied in phosphate buffer with pH = 7.4 in 37 °C under stirring. All the release kinetic curves are fitted by the power law and Higuchi equations. The fitting of the power law equation was separately done as for the released amount up to 60% or 100%. The materials show slow, long-term and sustained release of folic acid from mesoporous NFM-1 silica, which establishes a new foundation for the potential application in drug delivery and bioimaging.
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Keywords: FOLIC ACID; NFM-1; ORDERED MESOPOROUS MATERIALS; TARGETED DRUG DELIVERY

Document Type: Research Article

Publication date: 2010-11-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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