Internalization, Translocation and Biotransformation of Silica-Coated Titanium Dioxide Nanoparticles in Neural Stem Cells

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Abstract:

Nanotechnology has gained massive applications in the fields of biology and pharmacology. Recently, more research attention has been paid to explore the interaction between nanoparticles (NPs) and cells, in particular, the entry of NPs into cells. Herein, we focus on the internalization of the FITC-labeled silica-coated titania NPs (FITC-TiO2@SiO2 NPs) in neural stem cells (NSCs) and their subsequent translocation. Various microscopic techniques, such as confocal-laser-scanning microscopy (CFLSM), transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used to track the time-dependent pathway of NPs in cells. It was found that NPs traversed cell membrane and localized around the cell nucleus. Most NPs congregated in lysosomes and were transformed by lysosomes after 48 h co-incubation.

Keywords: BIOTRANSFORMATION; INTERNALIZATION; NEURAL STEM CELLS; TITANIUM DIOXIDE NANOPARTICLES; TRANSLOCATION

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2010.2824

Publication date: November 1, 2010

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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