Core/Shell Nanoparticles for pH-Sensitive Delivery of Doxorubicin
Authors: Oh, Keun Sang; Um, Yun Sik; Lee, Jin Ho; Cho, Sun Hang; Lee, Kyung Eun; Han, Sung Sik; Kim, Dongmin; Yuk, Soon Hong
Source: Journal of Nanoscience and Nanotechnology, Volume 10, Number 10, October 2010 , pp. 6967-6971(5)
Publisher: American Scientific Publishers
Abstract:Core/shell nanoparticles with lipid core were prepared and characterized as pH-sensitive delivery system of anticancer drug. The lipid core is composed of drug-loaded lecithin and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freeze-drying of drug-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a pH-sensitive drug delivery system for anticancer drug, doxorubicin was loaded into the core/shell nanoparticles and the drug loading amount and drug release behavior in response to pH change were observed.
Document Type: Research Article
Publication date: October 2010
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