Efficient Conjugation Doxorubicin to Bacterial Magnetic Nanoparticles via a Triplex Hands Coupling Reagent

Authors: Guo, Lin; Huang, Ji; Zheng, Li-Min

Source: Journal of Nanoscience and Nanotechnology, Volume 10, Number 10, October 2010 , pp. 6514-6519(6)

Publisher: American Scientific Publishers

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Abstract:

By using a novel triplex "hand" coupling reagent, tris-succinimidyl aminotriacetate (TSAT), doxorubicin loading efficiency of BMP can be greatly enhanced in comparison with that of dual functional linkers. The drug loading ratio of doxorubicin-coupled bacterial magnetic nanoparticles produced by this method (DBMP-T) is 62%. DBMP-T disperse well, have a narrow size distribution, exhibit a high magnetic response, is sensitive to pH to facilitate drug release and are strongly cytotoxic to HePG2 and MCF-7 cancer cells.

Keywords: BACTERIAL MAGNETIC NANOPARTICLES; DOXORUBICIN; MAGNETOSOME; DRUG CARRIER; TRIS-SUCCINIMIDYL AMINOTRIACETATE

Document Type: Research article

DOI: http://dx.doi.org/10.1166/jnn.2010.2543

Publication date: 2010-10-01

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Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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