Efficient Conjugation Doxorubicin to Bacterial Magnetic Nanoparticles via a Triplex Hands Coupling Reagent
Authors: Guo, Lin; Huang, Ji; Zheng, Li-Min
Source: Journal of Nanoscience and Nanotechnology, Volume 10, Number 10, October 2010 , pp. 6514-6519(6)
Publisher: American Scientific Publishers
Abstract:By using a novel triplex "hand" coupling reagent, tris-succinimidyl aminotriacetate (TSAT), doxorubicin loading efficiency of BMP can be greatly enhanced in comparison with that of dual functional linkers. The drug loading ratio of doxorubicin-coupled bacterial magnetic nanoparticles produced by this method (DBMP-T) is 62%. DBMP-T disperse well, have a narrow size distribution, exhibit a high magnetic response, is sensitive to pH to facilitate drug release and are strongly cytotoxic to HePG2 and MCF-7 cancer cells.
Document Type: Research article
Publication date: 2010-10-01
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