Fabrication of Microneedles Using Two Photon Polymerization for Transdermal Delivery of Nanomaterials
Authors: Doraiswamy, Anand; Ovsianikov, Aleksandr; Gittard, Shaun D.; Monteiro-Riviere, Nancy A.; Crombez, Rene; Montalvo, Eva; Shen, Weidian; Chichkov, Boris N.; Narayan, Roger J.
Source: Journal of Nanoscience and Nanotechnology, Volume 10, Number 10, October 2010 , pp. 6305-6312(8)
Publisher: American Scientific Publishers
Abstract:Microneedle devices for transdermal delivery of nanoscale pharmacologic agents were fabricated out of organically-modified ceramic (Ormocer®) materials using two photon polymerization. Out-of-plane hollow microneedle arrays with various aspect ratios were fabricated using this rapid prototyping process. Human epidermal keratinocyte (HEK) viability on Ormocer® surfaces fabricated using two photon polymerization was similar to that on control surfaces. Nanoindentation studies were performed to determine hardness and Young's modulus values for Ormocer® materials. Microneedles were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration. Our results suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents.
Document Type: Research article
Publication date: 2010-10-01
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