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Biodegradable Nano-Polymeric System for Efficient Akt1 siRNA Delivery

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Abstract:

Biodegradable nano-polymeric carrier composed of polycaprolactone (PCL) and polyethylenimine (PEI) (BNPP) was successfully synthesized for the delivery of sh/siRNA in lung cancer cells. BNPP efficiently and safely delivered siRNA in lung cancer cells. BNPP-delivered Akt1 siRNA silenced Akt1 protein, and reduced the cancer cell survival, proliferation, malignancy and metastasis.

Keywords: AKT1 PROTEIN; GENE DELIVERY; LUNG CANCER; NANOCARRIERS; NONVIRAL VECTORS; POLYCAPROLACTONE; POLYMERIC CARRIER; SIRNA DELIVERY

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2010.2228

Publication date: May 1, 2010

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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