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Nano-Inspired Fibrous Matrix with Bi-Phasic Release of Proteins

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Nanofibrous matrix was fabricated for the purpose of obtaining bi-phasic protein releases from a single protein delivery system. A block copolymer composed of poly(ethylene glycol) and poly(-caprolactone) was co-electrospun with protein solutions through a dual nozzle electrospinning system. Surface-exposed amine groups of the protein-encapsulating nanofiber at an aqueous phase were chemically conjugated to the carboxyl groups of another protein for surface-immobilization. The surface-immobilized proteins and the core-encapsulated proteins in the nanofibers were characterized by scanning electron microscopy and confocal microscopy. Encapsulation efficiency of protein in the core of the nanofiber was increased when poly(vinyl alcohol) was mixed in the protein solution. Flow rate ratios of protein solutions to polymeric solutions significantly affected encapsulation efficiency of proteins in the nanofiber, where high flow rate ratios increased encapsulation efficiencies of proteins in the nanofiber. Release profiles of the immobilized proteins and the encapsulated proteins from the nanofiber were examined for 4 days. The encapsulated proteins showed initial burst profiles while the surface-immobilized proteins showed no or minimal release of proteins for the release period. Thus, the nano-inspired fibrous matrix can be potentially employed to fabricate a drug delivery device with a bi-phasic release profile of proteins.


Document Type: Research Article


Publication date: May 1, 2010

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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