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The Immunotherapeutic Effect of Fe3O4 Nanoparticles as Adjuvants on Mice H22 Live Cancer

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Abstract:

The aim of this paper is to prepare Fe3O4 nanoparticles and study its immunotherapeutic effect as adjuvants on mice H22 live cancer. The Fe3O4 nanoparticles were prepared by chemical coprecipitation route. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Energy Dispersive Analysis (EDS) were used to characterize Fe3O4 nanoparticles. The Fe3O4 nanoparticles were compared with the common alum adjuvants for its ability to induce immunity to inhibit tumor growth rate by prophylactic and therapeutic studies. Results indicated that Fe3O4 nanopaticles adsorbed autovaccine took great advantages over the common alum adjuvants after subcutaneous injection, raised the mass inhibitory rate of tumor, boosted the activity of cytotoxicity and enhanced the level of IFN-γ cytokine. Thus, we concluded that Fe3O4 nanoparticles as adjuvants had great potential for enhancing anti-tumor immune response.

Keywords: AUTOLOGOUS TUMOR VACCINE; FE3O4 NANOPARTICLES; IMMUNOTHERAPY; MICE H22 LIVE TUMOR

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2010.1591

Publication date: 2010-01-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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