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Synthesis of Surface Modified Mesoporous Materials via Co-Assemble Route and Their Drug Release Properties

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Abstract:

A series of mesostructured Mn-MCM-41 composites were synthesized via a co-assembly route with tetraethylorthosilicate (TEOS) and manganese sulfate (MnSO4) as silica and manganese sources, respectively. And a model drug of cephanone was introduced via physical adsorption process into the channels of mesoporous silica, which could be used as the Mn-MCM-41 type mesoporous silica-based drug controlled-release delivery system. XRD, TEM, FT-IR, EDS and N2 adsorption–desorption were used to characterize the structural and textural properties of Mn-MCM-41 composites. The investigations showed that the addition of a small amount of manganese species was favorable for the long-range ordered structure of the mesoporous composites, whereas the ordered mesostructure was partially or completely distorted when the loaded manganese increased. The characterizations of cephanone loaded Mn-MCM-41 and in vitro release studies showed that the in vitro releases of cephanone in the ordered mesoporous materials follow an anomalous non-Fick's transport, and the impregnated manganese species had great influences on the release rate of cephanone from mesopores.

Keywords: CEPHANONE; COMPOSITES; DRUG RELEASE; MESOPOROUS MATERIALS; SILICA

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2009.1351

Publication date: November 1, 2009

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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