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Nanoparticles for Dentine Tubule Infiltration: An In Vitro Study

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Nanosized particles of hydroxyapatite were produced by a hydrothermal synthesis technique. Reaction time and starting pH were varied in order to produce a range of particle dimensions and morphologies. The particles were suspended in alcohol and used for in-vitro trials of dentinal tubule infiltration in etched sections of clinically extracted human molars. Particles were of rod-like morphology, and decreased in aspect ratio as the starting pH was raised. Particles prepared at pH 12 had a mean length of ∼70 nm and diameter of ∼30 nm. These showed the most promising infiltration results, with up to 90% of the tubules being fully or partially occluded. Comparisons were made with commercially-available 40 nm spherical silica particles. Information on the depth of infiltration was obtained from sections of dentine prepared using focussed ion beam milling (FIB-SEM).


Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2009.1330

Publication date: November 1, 2009

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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