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Self-Assembled Nanostructures of Oleic Acid and Their Capacity for Encapsulation and Controlled Delivery of Nutrients

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Abstract:

A simple preparation method for a nutrient delivery system is presented using nanostructures of oleic acid embedded in canola oil by a two step synthesis procedure. Oleic acid nanostructures in the form of micelles and vesicles were initially prepared and their ability to encapsulate vitamin-C, used as a model nutrient, was evaluated. Dynamic Light Scattering (DLS)analysis and Transmission Electron Microscopy (TEM) confirmed the formation of micelles and vesicles with diameters of 150 nm and 540 nm respectively. Supramolecular structural transformations were observed at specific temperatures, and coincided with the release of a considerable amount of encapsulants followed by a controlled and time bounded release. UV-Vis spectroscopy and various other thermochemical analytical techniques were employed to illustrate the structural transformations and specific environmental stimuli-responsive release of encapsulated materials. The nutrition-enriched nanostructures were successfully transferred to canola oil and the physico-chemical properties evaluated.

Keywords: CONTROLLED DELIVERY; ENCAPSULATION; MICELLES AND VESICLES; NUTRIENT DELIVERY SYSTEM; SELF-ASSEMBLY

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2009.1363

Publication date: 2009-11-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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