In Vitro Behavior of Multifunctionalized Fullerene-Warfarin Conjugates
Abstract:In this study we have covalently linked the anticoagulant warfarin to polyfunctionalized fullerenes. The objective was to explore the possibility of modifying the biological profile of a drug by covalent binding to functionalized fullerene. We have chosen warfarin as a model compound because it a widely used drug. We have analyzed the stability in vitro of the conjugates and found that the drug is released from the carbon support only after incubation in mouse plasma.
Document Type: Research Article
Publication date: 2009-10-01
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