Multifunctional Nano-Micelles Formed by Amphiphilic Gold-Polycaprolactone-Methoxy Poly(ethylene glycol) (Au-PCL-MPEG) Nanoparticles for Potential Drug Delivery Applications
Abstract:Multifunctional nano-micelles formed by amphiphilic gold-polycaprolactone-methoxy poly(ethylene glycol) (Au-PCL-MPEG) nanoparticles were synthesized and evaluated for potential drug delivery applications. Amphiphilic Au-PCL-MPEG nanoparticles were synthesized by the ring-opening polymerization of -caprolactone (-CL) using pre-synthesized 11-mercaptoundecanol stabilized Au (Au-MUD) nanoparticles in the presence of stannous octoate as a catalyst followed by esterification with MPEG-COOH. The amphiphilic Au-PCL-MPEG nanoparticles and the resulting nano-micelles formed in an aqueous solution have been characterized by a number of techniques, including 1H-NMR spectroscopy, transmission electron microscopy (TEM), fluorescent spectroscopy, and UV-vis spectroscopy. The critical aggregation concentration (CAC) of the micelles was 4 mg/l. The average size of the Au-PCL-MPEG nano-micelles below and above the CAC was 22 and 48 nm, respectively, as determined by the TEM. The controlled release of a model hydrophobic drug, 5-flurouracil, encapsulated in the Au-PCL-MEPG nanomicelles that lasted for more than four days was observed. In addition, due to the presence of Au nano-core, these Au-PCL-MPEG nanoparticles can potentially serve as a contrast agent for imaging (e.g., computed tomography (CT) imaging) and/or a nanoheater (e.g., in response to near infrared light) for photothermal therapy for cancer treatments.
Document Type: Research Article
Publication date: October 1, 2009
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- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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