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Evaluation of Nanofabricated Ginseng Extract Powders

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Abstract:

The objective of this study is to investigate the nano-fabrication method for ginseng extract powders (GEPs) and detect the differences in physical and chemical properties, and cytotoxicity of GEPs before and after fabrication. White ginseng was used as the raw material to produce the GEPs (Sample A). After grinding, the GEPs passed a 40-mesh sieve (particle size < 105 m) and was named as Sample B. The residue (particle size > 105 m) was named as Sample C. Samples A and B were used for nanofabrication though the use of a high-energy ball mill. Sample B was ground for 3 hr (Sample D) and 1 hr (Sample E), while Sample A was ground for 3 hr (Sample F) and 1 hr (Sample G). Nanoparticles of GEPs with ranges of 300 nm∼1 m and 500 nm∼3 m were produced. The heavy metal content (As, Cd, Co, Cu, Fe, Hg, Mn, Ni, Pb, Se and W) of Samples A–G were all under the maximum residue limit. Sample C contained a higher amount of yellow crystal material and had the highest ginsenoside contents and antioxidant capacity. There were enrichments of ginsenosides (∼1.3 fold) and antioxidant capacities (∼1.6 fold) in Sample C compared to Sample A. Moreover, after nano-fabrication, the antioxidant capacity was not changed significantly. However, the cellular growth enhancement ability was increased significantly. Samples F and G had the higher cellular growth enhancement ability and improved the cellular growth of L929 cells about 1.3 times as compared to Sample A. In future studies, Sample C will be used for nanofabrication in order to enhance the curative efficiency of ginseng.

Keywords: ANTIOXIDANT CAPACITY; CELLULAR GROWTH ENHANCEMENT; CYTOTOXICITY ASSAY; GINSENG; GINSENOSIDES; MICRO/NANO-FABRICATION

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2009.M18

Publication date: 2009-07-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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