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Nanostructured Multilayer Coatings Combining Chitosan with Bioactive Glass Nanoparticles

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Abstract:

There is an increasing interest in conceiving biomimetic coatings and films for a variety of biomedical applications. Biodegradable multilayer coatings combining a polycation (chitosan) and an anionic element (bioactive glass nanoparticles) were developed by sequential deposition. Quartz crystal microbalance showed that this methodology may be used to produce tunable and viscoelastic nanostructured multilayers upon increasing the number of layer-by-layer cycles. The hypothesis of this concept, which was also verified in this work, is that such robust coatings, inspired by the ordered and tough brick-and-mortar structure of nacre, could also induce the formation of apatite upon immersion in simulated body fluid with ion concentrations similar to those in human plasma. The proposed method could be also employed in the coatings of substrates with complex geometries, including scaffolds for bone tissue engineering applications, and thus constitutes a new technological solution to improve osteoconductivity of a variety of implants for orthopedic applications.

Keywords: BIOACTIVE GLASS; BIOMINERALIZATION; LAYER-BY-LAYER; POLYELECTROLYTES; POLYSACCHARIDE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2009.389

Publication date: March 1, 2009

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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