@article {Hsiao:2009:1533-4880:1388,
title = "Cellular Behavior Change of Macrophage After Exposure to Nanoparticles",
journal = "Journal of Nanoscience and Nanotechnology",
parent_itemid = "infobike://asp/jnn",
publishercode ="asp",
year = "2009",
volume = "9",
number = "2",
publication date ="2009-02-01T00:00:00",
pages = "1388-1393",
itemtype = "ARTICLE",
issn = "1533-4880",
eissn = "1533-4899",
url = "https://www.ingentaconnect.com/content/asp/jnn/2009/00000009/00000002/art00163",
doi = "doi:10.1166/jnn.2009.C163",
keyword = "MAGNETIC NANOPARTICLES, MACROPHAGE, MAGNETIC RESONANCE IMAGING",
author = "Hsiao, J.-K. and Weng, T.-I. and Tai, M.-F. and Chen, Y.-F. and Wang, Y.-H. and Yang, C.-Y. and Wang, J.-L. and Liu, H.-M.",
abstract = "Magnetic nanoparticles (MNPs) are few of the nanoparticles used clinically. When MNPs are delivered into human body, they are ingested by macrophages. We evaluated the cellular response of macrophage after MNPs loading. In face of stimulation by lipopolysaccharide, a strong stimulant
derived from bacterial cell wall, MNPs loaded macrophage exhibited decreased phagocytic activity and decreased generation of cytokines such as TNF-, IL-1 whereas increased nitric oxide generation was noticed. Although these changes might decrease bactiericidal activity,
it also alleviates the risk of senses, a life threatening phenomenon in infection patients. The finding has significant implications on nanoparticle based targeted drug delivery.",
}