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The Pulmonary Toxicity of Multi-Wall Carbon Nanotubes in Mice 30 and 60 Days After Inhalation Exposure

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Abstract:

The pulmonary toxicity, induced by multi-wall carbon nanotubes in mice, was studied after 30-day and 60-day inhalation exposure. The mice were exposed to multi-wall carbon nanotubes aerosol with weighted mean concentration of 32.61 mg/m3, once in very two days, 6 hours in an exposure day. After 30-day and 60-day inhalation exposure, the pulmonary toxicity of multi-wall carbon nanotubes was assessed using biochemical indices in bronchoalveolar lavage fluid and pathological examination. It was found that the aerosolized multi-wall carbon nanotubes did not induce obvious pulmonary toxicity in 30-day exposure group, but induced severe pulmonary toxicity in 60-day exposure group.

Keywords: INHALATION EXPOSURE; MULTI-WALL CARBON NANOTUBES; PULMONARY TOXICITY

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2009.C162

Publication date: 2009-02-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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