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Fabrication and Characterization of Chitosan-Poly(acrylic acid) Magnetic Nanospheres

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Abstract:

Iron oxide nanoparticles modified with meso-2,3-dimercaptosuccinic acid (DMSA), were encapsulated with a natural polymer with abundant primary amino groups, chitosan (CS), to improve their biocompatibility. Characterization was performed using Fourier transform infrared spectroscopy, thermogravimetirc analysis, transmission electron microscope analyses, vibrating sample magnetometer, zeta potential analyzer. It was found that highly ordered spherical aggregates with a mean diameter of 98 nm are obtained. The formation of aggregates depended on cross-linking of acrylic acid (AA) monomers and CS. These biodegradable CS-PAA polymer magnetic nanospheres might be useful for various biomedical applications.

Keywords: ACRYLIC ACID; CHITOSAN; MAGNETIC NANOSPHERES

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2009.C139

Publication date: February 1, 2009

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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