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Electrical-Sensitive Nanoparticle Composed of Chitosan and Tetraethyl Orthosilicate for Controlled Drug Release

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In the present study, the nanoparticles with size of 50–130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-controlled release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism. The "slow-to-burst" and "near-zero" release of the myoglobin can be effectively controlled by applying DC electric field between "on" and "off."
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Keywords: ELECTRIC-STIMULI; NANOPARTICLE; POLYELECTROLYTE

Document Type: Research Article

Publication date: 01 February 2009

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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