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Application of the Blending of PNIPAM-co-PS Nanofibers with Functionalized Au Nanoparticles for the High-Sensitive Diagnosis of Cancer Cells

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Abstract:

The blending of poly(N-isopropylacrylamide)-co-polystyrene nanofibers with functionalized gold nanoparticles was explored to form the new nanocomposites to facilitate the accumulation of daunorubicin inside leukemia cells and potentially enhance the cure efficiency. The synergistic enhancement effect of the nanocomposites on the drug uptake of daunorubicin in drug resistant leukemia K562 cells has been observed by using electrochemical and confocal fluorescence microscopy studies. The results suggest that these nanocomposites could be utilized to facilitate the drug delivery and realization of the early diagnosis of the respective cancer cells, suggesting the potential valuable application in the relative biomedical and bioanalysis areas.

Keywords: DRUG RESISTANT CANCER CELLS; GOLD NANOPARTICLES; POLYMER NANOFIBERS

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2009.C044

Publication date: 2009-02-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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