Novel Sterecomplexed Sol–Gel Transition Hydrogels Prepared from Physical Packing of Self-Assembled PEO-PPO-PEO and PPO-PEO-PPO Copolymer Nanoscale Micelles

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Abstract:

A new class of stereocomplex-induced hydrogels was synthesized based on self-assembled PEO-PPO-PEO and PPO-PEO-PPO copolymers having multiple hydroxyl groups in the PPO segment. The copolymers were grafted with enantiomeric oligo(L-lactic acid) or oligo(D-lactic acid) chains using ring opening polymerization onto the PPO segment. WAXS and DSC analysis were used to investigate the stereocomplex formation of the equimolar mixture of the copolymers. The copolymer hydrogels having stereocomplexed crystalline domains as crosslinking loci exhibited significantly altered temperature-sensitive sol–gel transition behaviors, and showed more delayed erosion and sustained protein release behaviors, compared to Pluronic F127 copolymer hydrogels. The current hydrogels are expected to be used as useful injectable hydrogel materials for macromolecular drug delivery.

Keywords: DRUG DELIVERY; HYDROGEL; MICELLE; PLURONIC; TEMPERATURE-SENSITIVE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2008.1384

Publication date: October 1, 2008

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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