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Fabrication and Characterization of Surface-Derivatized Porous Silicon "Smart Particles" for Detection of Streptavidin

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Biotin/silole-derivatized distributed Bragg reflectors porous silicon (DBR PSi) smart particles for the detection of streptavidin have been developed. DBR PSi fabricated by applying a computer-controlled periodic square current waveform was prepared for the application as a label-free biosensor based on PSi interferometer. The fabrication, optical characterization, and surface derivatization of DBR smart particles were described. Biotin/silole-derivatized DBR smart particles displaying dual optical properties such as photoluminescence (λ em = 505 nm) and reflectivity(λ max = 607 nm) were obtained from the DBR PSi film in organic solution by using ultra-sono method. The surface and cross sectional morphology of DBR smart particles were obtained with FE-SEM. FT-IR spectroscopy was used to characterize the oxidation and functionalization of DBR smart particles. Binding of the streptavidin into the biotin-derivatized DBR smart particles displayed a change in refractive index. A red-shift of reflectivity by 14 nm in the reflectivity spectrum was observed, when the biotin-modified DBR smart particles were exposed to a flow of PBS buffer solution containing streptavidin.


Document Type: Research Article


Publication date: 2008-10-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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