Synthesis of Poly(ethylene glycol)-Polydiacetylene Conjugates and Their Micellar and Chromic Characteristics
Abstract:In this report, novel polymer-lipid conjugates were synthesized and their unique micellar and chromic properties were studied. The conjugates were synthesized by the liquid-phase peptide synthesis method using methoxy(polyethylene glycol)-amine (mPEG-NH2, MW2000) as a supporting material. One and two 10,12-pentacosadiynoic acid (PCDA) groups were conjugated to mPEG-NH2 to prepare mPEG-PCDA and mPEG-PCDA2, respectively. The polymer conjugates could form nanometersized micelles in aqueous media and be further polymerized under the exposure of UV 254 nm due to the UV sensitive nature of PCDA. It was observed that mPEG-PCDA2 micelle showed very distinctive photochromism and thermochromism in response to UV or heat, whereas mPEG-PCDA did not display any chromic properties. Moreover, a distinctive chromic property change was observed by adding α-cyclodextrin as a model biological molecule to the micelle solution. Due to their unique properties such as high water-solubility, cross-linkable micelle formation with a nano-scaled size, and stimuli-responsive chromic nature, the polymer-lipid conjugates would be useful for various biomedical applications, in particular as a nano-carrier for drug delivery and biosensor.
Document Type: Research Article
Publication date: 2008-10-01
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